ARCH invests in life science companies that are pioneering in the fields of biopharmaceuticals, bioinformatics, gene therapy, medical devices, and other breakthrough technology.

ARCH is one of the leading early-stage biotechnology investors nationwide and known for our focus on revolutionary platform technologies. We were early investors in groundbreaking technologies addressing:

• Vaccines (Aviron)
• Pain therapy (Adolor and NeurogesX)
• RNAi therapy (Alnylam Pharmaceuticals)
• Alternative antibodies (Trubion Pharmaceuticals)
• Anti-aging therapy (Elixir Pharmaceuticals)
• Genomics (deCode Genetics)
• Gene therapy (GenVec)
• Microfluidics (Caliper Life Sciences)
• Apoptosis (IDUN Pharmaceuticals)
• Nanotechnology (Nanosys)
• Addressable arrays (Illumina)
• Chemistry targeting (XenoPort)
• Chemistry outsourcing (Array BioPharma)
• Critical care therapy (Ikaria)

We are open-minded and future-oriented in the search for new high impact technology platforms.

If we believe in the science, we will take the concept to its commercial potential.

ARCH portfolio companies are delivering innovations in:

• Biotechnology/pharmaceuticals
• Informatics
• Medical instrumentation

Achaogen, Inc. San Francisco, CA Therapeutics for combating the increasing bacterial resistance to antibiotics
Adolor Corporation Exton, PA Analgesic pharmaceuticals NASDAQ: ADLR
Agios Pharmaceuticals, Inc. Cambridge, MA Cancer therapies addressing cellular metabolism
Allozyne, Inc. Seattle, WA Enhanced potency, tolerability and pharmacology of protein based therapeutics
Alnylam Holdings, Inc. Concord, MA RNA interference-based pharmaceuticals NASDAQ: ALNY
Apoptos, Inc. San Diego, CA Anti-cancer therapies based on apoptosis research Acquired by Receptos Pharmaceuticals, Inc.
Array BioPharma, Inc. Boulder, CO Chemical intermediate sales and chemistry outsourcing NASDAQ: ARRY
Aviron, Inc. Mountain View, CA Live attenuated vaccines including FluMist NASDAQ: AVIR Acquired by MedImmune, Inc. NASDAQ: MEDI
BIND Biosciences, Inc. Cambridge, MA Biopharmaceutical firm developing therapeutic targeted nanoparticles
Caliper Life Sciences, Inc. Mountain View, CA Microfluidics ("lab on a chip") for research instrumentation and drug screening NASDAQ: CALP
Cambrios Technologies Corp. Sunnyvale, CA "Directed-evolution" technology platform employing molecular biology to synthesize nanostructures and advanced materials for use in electronics
Celula, Inc. La Jolla, CA Developing proprietary diagnostic tools
CEPTYR, Inc. Bothell, WA Application of protein tyrosine phosphatases (PTPs) technology to pharmaceutical discovery addressing immunosuppression, Type II diabetes, obesity, and oncology
Chiasma Corp. Jerusalem, Israel New drug development technology enabling drugs to be switched from injectable to oral, creating new indications or improved labels
Elixir Pharmaceuticals, Inc. Cambridge, MA Discovery of therapeutics that slow or counteract age-related diseases and conditions
Ensemble Discovery Corp. Cambridge, MA Chemical synthesis platform using DNA-programmed chemistry for the rapid discovery of chemical compounds and reactions
Fate Therapeutics, Inc. Seattle, WA Adult stem cell biology
GenVec, Inc. Gaithersburg, MD Gene therapy for cardiovascular disease and cancer NASDAQ: GNVC
GPC-Rx Corp. Seattle, WA Platform for analyzing GPCRs (proteins) to aid in drug design
IDUN Pharmaceuticals, Inc. LaJolla, CA Discovery of small molecule drugs that interfere with the programmed cell death processes for the treatment of hyperproliferative and degenerative diseases Acquired by Pfizer NYSE: PFE
Ikaria, Inc. Seattle, WA Metabolic potentiation for critical care medicine
Illumina, Inc. San Diego, CA Fiber optic arrays for use in genomics and proteomics NASDAQ: ILMN
ISB Accelerator Corp. Seattle, WA Building the next generation of life-enhancing biotech companies by providing resources critical to the development of nascent biotechnologies
Kythera Biopharmaceuticals, Inc. Woodland Hills, CA Aesthetic and dermatologic prescriptive therapies
Limerick BioPharma, Inc. South San Francisco, CA Analgesics with reduced side effects
Lycera Corp. Ann Arbor, MI Mitochondrial biology platform for discovery of small molecules related to diseases/conditions with abnormal cell activity
Magen BioSciences, Inc. Cambridge, MA Therapies to improve the health and appearance of skin and hair Acquired by Pharmaceutical Product Development, Inc. NASDAQ: PPDI
Mirina Corp. Seattle, WA MicroRNA therapeutics
Nanosys, Inc. Palo Alto, CA Technology utilizing nanowires, nanorods and nanocrystals with applications in electronics, biology, chemistry and quantum computing
NeurogesX, Inc. San Carlos, CA Pharmaceuticals for intractable pain relief NASDAQ: NGSX
Nura, Inc. Seattle, WA Treatments for neurodegenerative diseases and behavioral disorders Acquired by Omeros Corp.
PhaseRx, Inc. Seattle, WA siRNA drug delivery technology
Qwell Pharmaceuticals, Inc. Houston, TX Plant-derived therapeutics to treat cancers, autoimmune and inflammatory diseases
Sapphire Energy Corp. San Diego, CA Renewable gasoline from sunlight, carbon dioxide and photosynthetic microorganisms
Sorbent Therapeutics, Inc. Vernon Hills, IL Fluid-retaining polymers for therapeutics to treat kidney disease and other conditions
Theraclone Sciences, Inc. Seattle, WA Tumor-specific cancer antibody-based therapeutics
Surface Logix, Inc. Brighton, MA Biophysical chemistry platform creating small molecule drugs with enhanced functionality
Trubion Pharmaceuticals, Inc. Seattle, WA Small molecule therapies to combat autoimmune and inflammatory diseases NASDAQ: TRBN
Variation Biotechnologies, Inc. Gatineau, Quebec, Canada Platform focused on bioinformatic design of vaccines for the influenza, HIV, Hepatitis C, SARS, and Dengue
VentiRx Pharmaceuticals, Inc. San Diego, CA Developing immunoregulatory therapies based on innate immunity
VLST, Inc. Seattle, WA Platform for improved identification and validation of cell targets for drug development
Xcyte Therapies, Inc. Seattle, WA Immune therapy for cancer NASDAQ: XCYT Merged with Cyclacel Group plc NASDAQ: CYCC
XenoPort, Inc. Palo Alto, CA Enhanced drug delivery NASDAQ: XNPT
deCode Genetics, Inc. Reykjavik, Iceland Genomics information derived from the population of Iceland NASDAQ: DCGN
Fast Track Systems, Inc. Conshohocken, PA Web-based clinical trials software Acquired by Medidata Solutions, Inc. NASDAQ: MDSO
Genomica Corporation Boulder, CO Bioinformatics software NASDAQ: GNOM Acquired by Exelixis, Inc. NASDAQ: EXEL
MedVantx, Inc. San Diego, CA Patient-centric approach to initiate medication therapy in physician offices
NexCura, Inc. Seattle, WA Provider of online decision support services for patient  communities Acquired by The Thomson Corp. NYSE: TOC
Plectix BioSystems, Inc. Seattle, WA Sophisticated computer modeling of complex biological and chemical systems
EKOS Corporation Bothell, WA Ultrasound drug delivery
Quanterix, Inc. Cambridge, MA Single molecule and single cell analysis platform
R2 Technology, Inc. Sunnyvale, CA Mammography "image checker" for assisting in the detection of breast cancer Acquired by Hologic, Inc. NASDAQ: HOLX
Therus Corporation Seattle, WA Therapeutic ultrasound

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