Life Sciences
San Francisco, CA
Achaogen, Inc.
Therapeutics for combating the increasing bacterial resistance to antibiotics
Seattle, WA
Acylin Therapeutics Corp.
Small molecule drug development
Exton, PA
Adolor Corporation
NASDAQ: ADLR
Analgesic pharmaceuticals
Acquired by Cubist Pharmaceuticals, Inc.
NASDAQ: CBST
Cambridge, MA
Agios Pharmaceuticals, Inc.
NASDAQ: AGIO
Cancer therapies addressing cellular metabolism
Seattle, WA
Allozyne, Inc.
Enhanced potency, tolerability and pharmacology of protein based therapeutics
Concord, MA
Alnylam Holdings, Inc.
NASDAQ: ALNY
RNA interference-based pharmaceuticals
Boulder, CO
Array BioPharma, Inc.
NASDAQ: ARRY
Chemical intermediate sales and chemistry outsourcing
Mountain View, CA
Aviron, Inc.
NASDAQ: AVIR
Live attenuated vaccines including FluMist
Acquired by MedImmune, Inc.
NASDAQ: MEDI
Cambridge, MA
BIND Therapeutics, Inc.
NASDAQ: BIND
Biopharmaceutical firm developing therapeutic targeted nanoparticles
San Diego, CA
Blackthorn Therapeutics, Inc.
Novel biological insights into central nervous system therapies
Cambridge, MA
Bluebird Bio, Inc.
NASDAQ:BLUE
Gene therapies for childhood cerebral adrenoleukodystrophy (CCALD) and beta-thalassemia/sickle cell anemia
Mountain View, CA
Caliper Life Sciences, Inc.
NASDAQ: CALP
Pioneer in microfluidics ("lab on a chip") for research instrumentation and drug screening

Acquired by PerkinElmer, Inc.
NYSE: PKI
San Francisco, CA
Cenexys, Inc.
Therapies to clear senescent cells from the body to treat age-related diseases
Boston, MA
Chiasma Corp.
New drug development technology enabling drugs to be switched from injectable to oral, creating new indications or improved labels
Cambridge, MA
Ensemble Therapeutics, Inc.
Chemical synthesis platform using DNA-programmed chemistry to develop synthetic macrocycle drugs called Ensemblins™
La Jolla, CA
Fate Therapeutics, Inc.
NASDAQ: FATE
Adult stem cell biology
Gaithersburg, MD
GenVec, Inc.
NASDAQ: GNVC
Gene therapy for cardiovascular disease and cancer
Seattle, WA
Groove BioPharma Corp.
MicroRNA therapeutics
Lafayette, CA
Hua Medicine, Inc.
Sourcing drug discovery technology in U.S. and China
LaJolla, CA
IDUN Pharmaceuticals, Inc.
Discovery of small molecule drugs that interfere with apoptosis
Acquired by Pfizer
NYSE: PFE
Hampton, NJ
Ikaria, Inc.
Biotherapeutics to address unmet medical needs of critically ill patients
Acquired by Madison Dearborn Partners
San Diego, CA
Illumina, Inc.
NASDAQ: ILMN
Fiber optic arrays for use in genomics
Seattle, WA
ISB Accelerator Corp.
Building the next generation of biotech companies by providing resources critical to the achievement of scientific proof-of-concept
Woodland Hills, CA
Kythera Biopharmaceuticals, Inc.
NASDAQ: KYTH
Aesthetic and dermatologic prescriptive therapies
Seattle, WA
Juno Therapeutics, Inc.
Curative cancer immunotherapy treatments
Ann Arbor, MI
Lycera Corp.
Mitochondrial biology platform for discovery of small molecules related to diseases/conditions with abnormal cell activity
San Carlos, CA
NeurogesX, Inc.
NASDAQ: NGSX
Pharmaceuticals for intractable pain relief
Acquired by Acorda Therapeutics, Inc.
Seattle, WA
Nura, Inc.
Treatments for neurodegenerative diseases and behavioral disorders
Acquired by Omeros Corp.
NASDAQ: OMER
Seattle, WA
Omeros Corp.
NASDAQ: OMER
Pharmaco Surgery™ drug platform to reduce trauma from surgical and medical procedures
Seattle, WA
Oncofactor Corp.
Cancer therapeutics that disrupt signaling pathways between tumors and the immune system
Cambridge, MA
Permeon Biologics, Inc.
Intracellular biotherapeutics platform to enhance drug delivery
Seattle, WA
PhaseRx, Inc.
siRNA drug delivery technology
Lexington, MA
Pulmatrix, Inc.
Inhaled therapeutics for respiratory disease and infections
San Diego, CA
Receptos, Inc.
NASDAQ: RCPT
GPCR drug discovery and development
Cambridge, MA
Sage Therapeutics, Inc.
Therapeutics to treat severe nerological conditions such as Fragile X and traumatic brain injury
Sunnyvale, CA
Sorbent Therapeutics, Inc.
Fluid-retaining polymers for therapeutics to treat kidney disease and other conditions
Watertown, MA
Syros Pharmaceuticals, Inc.
Mapping gene regulatory circuits and modulating gene expression factors
Seattle, WA
Theraclone Sciences, Inc.
Human monoclonal antibody platform with multiple therapeutic product candidates
Seattle, WA
Trubion Pharmaceuticals, Inc.
NASDAQ: TRBN
Alternate antibody scaffold platform company
Acquired by Emergent BioSolutions, Inc.
NYSE: EBS
Gatineau, Quebec, Canada
VBI Vaccines, Inc.
Vaccine technology platform company enabling the development of thermostable and oral vaccines
Seattle, WA
VentiRx Pharmaceuticals, Inc.
Developing immunoregulatory therapies based on innate immunity
Seattle, WA
VLST, Inc.
Virology-based platform for improved identification and validation of cell targets for therapeutic drug development
Seattle, WA
Xcyte Therapies, Inc.
NASDAQ: XCYT
Immune therapy for cancer
Merged with Cyclacel Group plc
NASDAQ: CYCC
Palo Alto, CA
XenoPort, Inc.
NASDAQ: XNPT
Enhanced drug delivery