Portfolio Companies Include

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908 Devices
Point-of-need chemical and biomolecular analysis devices
Abelian Therapeutics (Acquired)
Investigating glia factors in brain disease
Boston, MA
Accelerator Corp.
Systems biology incubator
Seattle, WA
Antibiotic therapeutics
San Francisco, CA | NASDAQ: AKAO
Acylin Therapeutics (Acquired)
Small molecule therapeutics
Chicago, IL & WA
Adesto Technologies (Acquired)
Non-volatile memory technology
Santa Clara, CA | NASDAQ: IOTS
Adolor (Acquired)
Analgesic therapeutics
Kenilworth, NJ & PA | NASDAQ: ADLR
Disease and pest resistant crops
Durham, NC
Agios Pharmaceuticals
Gene-targeted cancer therapeutics
Cambridge, MA | NASDAQ: AGIO
Animal feed enzyme
Medford, MA
Agtech Accelerator
Agriculture industry incubator
Durham, NC
Ahura Scientific (Acquired)
Advanced security instrumentation
Waltham, MA
Accountable care organizations
Bethesda, MD
ALIS (Acquired)
High-resolution microscopy
Peabody, MA
Alnylam Pharmaceuticals
RNAi therapeutics
Cambridge, MA | NASDAQ:  ALNY
Altos Labs
Cellular resilience and rejuvenation
San Diego, CA
Guangzhou, China
Apex Neuro Holdings
Wearable Technology for Personal and Medical Well-Being
Cambridge, MA
ApoGen Biotechnologies
Cancer therapeutics
Seattle, WA
Apropos Technology (Acquired)
Call center software
Oak Brook Terrace, IL | NASDAQ: APRS
Arbor Biotechnologies
Protein Discovery Platform for Therapeutics
Cambridge, MA
Array Biopharma
Chemistry sales & out-sourcing
Boulder, CO | NASDAQ: ARRY
Aspen Neuroscience
Regenerative medicine focused on Parkinson’s Disease
La Jolla, CA
Asteroid Therapeutics
Nuclear receptor biology drug discovery
San Carlos, CA
Autobahn Therapeutics
Thyromimetics drug discovery
San Diego, CA
Aviron (Acquired)
Vaccine therapeutics
Mountain View, CA | NASDAQ: AVIR
Beam Therapeutics
CRISPR base-editing platform
Cambridge, MA | NASDAQ: BEAM
Bellerophon Therapeutics
Cardiac therapeutics
BIND Biosciences
Nanoparticle-targeted therapeutics
Cambridge, MA | NASDAQ: BIND
Agricultural gene-editing techniques
Kobe, Japan
Bit Bio
Precise reprogramming of stem cells into any desired cell type
Cambridge, UK
Bitterroot Bio
Cardiovascular disease therapies
Palo Alto, CA
BlackThorn Therapeutics (Acquired)
CNS pharmaceuticals
San Francisco, CA
Bluebird Bio
Gene therapies
Cambridge, MA | NASDAQ:BLUE
Durham, NC
Boreal Genomics (Acquired)
DNA purification
Vancouver, Canada
Boundless Bio
Therapeutics based on ecDNA discoveries
La Jolla, CA
Brii Biosciences
Transforming China's public health
Shanghai, China & San Francisco, CA
Caliper Life Sciences (Acquired)
Microfluidics biomanufacturing
Carrick Therapeutics
Cancer therapeutics
Oxford, Ireland
CelebrateExpress (Acquired)
Web party supply site
Seattle, WA | NASDAQ: BDAY
CERO Therapeutics
Cellular immunotherapies
San Francisco, CA
Oral therapeutics replacement for injectables
Waltham, MA | NASDAQ: CHMA
Ciespace (Acquired)
3D modeling software
Columbia, MD
ClassMates Online (Acquired)
Web alumni host site
Seattle, WA
Codiak Biosciences
Cancer therapeutics
Cambridge, MA | NASDAQ: CDAK
Cooledge Lighting
Solid-state lighting
Richmond, Canada
Crystal IS (Acquired)
Nitride semiconductors
Fowlerville, MI
CStone Pharmaceuticals
China-based cancer therapeutics
Suzhou, China | HKEX: 2616
Cyclacel Pharmaceuticals
Immune system modulating therapeutics
Berkeley Heights, NJ & WA | NASDAQ:  CYCC
Cytrellis Biosystems
Aesthetic medicine
Woburn, MA
Dantz Development (Acquired)
Security software
Hopkinton, MA
deCODE Genetics (Acquired)
Population-based genomics database & diagnostics
Thousand Oaks, CA & Iceland & MA | NASDAQ:  DCGN
Denali Therapeutics
Neurodegenerative therapeutics
San Francisco, CA | NASDAQ:  DNLI
Dewpoint Therapeutics
Translating biomolecular condensate into therapeutics
Boston, MA
Gene-editing for organ transplantation
Cambridge, MA
Eichrom Technologies (Acquired)
Separations & polymer chemistry
Lisle, IL
Element Genomics (Acquired)
Genomics Discovery Platform
Durham, NC
Encoded Therapeutics
Precision gene therapies
South San Francisco, CA
Protein Analysis Platform
San Diego, CA
Ensemble Therapeutics
DNA chemical libraries
Cambridge, MA
Epirium Bio
Therapeutics for mitochondrial biogenesis and function
San Diego, CA
Re-engineering drug development and pricing models
Cambridge, MA | NASDAQ: EQRX
Erasing cancer with AI drug discovery platform
San Diego, CA | NASDAQ: ERAS
Everyday Learning (Acquired)
Mathematics curricular materials
Colombus, OH and Chicago, IL
Faraday Pharmaceuticals
Ischemic trauma therapies
Seattle, WA
FastTrack Systems (Acquired)
Clinical trials software
New York, NY & PA
Fate Therapeutics
Stem cell therapeutics
San Diego, CA | NASDAQ: FATE
Feelmore Labs
Innovative health and wellness technology company pioneering a new category of wearable devices that improve lives
Brooklyn, New York
Generate Biomedicines
Multi-disciplinary platform for developing protein therapeutics
Cambridge, MA
Genomica (Acquired)
Genomics software systems
Boulder, CO | NASDAQ: GNOM
Genomics Medicine Ireland (Acquired)
Gene-based therapeutics
Dublin, Ireland
Cardiovascular gene therapeutics
Gaithersburg, MD | NASDAQ: GNVC
Glympse Bio
Biological enzyme activity sensors for diagnostics
Cambridge, MA
Gossamer Bio
Therapeutics in immunology, inflammation, and oncology
San Diego, CA | NASDAQ: GOSS
Grail (Acquired)
Detect cancer early, when it can be cured.
Menlo Park, CA
GroundTruth Ag
Soil analysis tools
Research Triangle Park, NC
Happy Health
Consumer wearable bioinformatics devices
Brooklyn, NY
hC Bioscience
tRNA-based therapeutics for cancer and rare disease
Boston, MA
HI Bio
Precision immunology therapies
San Francisco, CA
Therapeutics to prevent cancer relapse and metastasis
New York, NY
Homology Medicines
In-vivo gene editing
Bedford, MA | NASDAQ: FIXX
Hua Medicine
Asia-based pharmaceutical development
Shanghai, China | HKEX: 2552
IDUN Pharmaceuticals (Acquired)
Apoptosis therapeutics
San Diego, CA
Ikaria (Acquired)
Critical care respiratory therapeutics
St. Louis, MO & NJ
Diagnostics screening platform
Santa Clara, CA | NASDAQ: ILMN
Precision immunology company
Cambridge, MA
Celiac Disease Therapies
Cambridge, MA
RFID electronics
Seattle, WA | NASDAQ: PI
ImproveNet, Inc
Web-based home improvement
Redwood City, CA | NASDAQ:  IMPV
Innovalight (Acquired)
Thin film nanotechnology
Palo Alto, CA
Machine learning for drug discovery
South San Francisco, CA
Intelligent Reasoning Systems (Acquired)
Optical inspection systems
Austin, TX
Interline Therapeutics
Protein community guided drug discovery
San Francisco, CA
Mobile network performance improvement
Schaumburg, IL
Jaguar Gene Therapy
Gene therapies for severe genetic diseases
Lake Forest, IL
Juno Therapeutics (Acquired)
Cancer immunotherapies
Seattle, WA | NASDAQ: JUNO
JUST Biotherapeutics (Acquired)
Therapeutics development & manufacturing
Seattle, WA
JW Therapeutics
China-based cancer therapeutics
Shanghai, China | HKEX: 2126
Karuna Therapeutics
Therapeutics for cognitive impairment
Kisbee Therapeutics
Neurodegenerative disease therapies based on lipid biology
Cambridge, MA
Kotura (Acquired)
Silicon photonic chips
Sunnyvale, CA
KSQ Therapeutics
Matching Genomic Function to Diseases
Cambridge, MA
Kura Oncology
Cancer therapeutics
San Diego, CA | NASDAQ: KURA
Kyra Clinical
Reimagining the clinical trials process
New York, NY
Kythera Biopharmaceuticals (Acquired)
Aesthetic medicine
Parsippany, NJ & CA | NASDAQ: KYTH
LifeMine Therapeutics
Biosynthetic therapeutics
Cambridge, MA
Lightcast Discovery
Microfluidic platform for complex and single cell analysis
Cambridge, UK
Tracking RNA via CRISPR Technology
San Diego, CA
Lodo Therapeutics (Acquired)
Therapeutics for Drug Resistant Bacteria
New York, NY
Lyell Immunopharma
Curative cell-based immunotherapeutics for cancer
San Francisco, CA & Seattle, WA | NASDAQ: LYEL
Maze Therapeutics
Targeting genetic modifiers that can protect against disease
San Francisco, CA
Medication control systems & software
San Diego, CA
Metabolic disease therapeutics
San Diego, CA | NASDAQ: MTCR
MicroOptical Devices (Acquired)
Semiconductor surface emitting lasers
Alhambra, CA & NM
Neuropsychiatric treatment using mobile/AI technology
Palo Alto, CA
Movidius (Acquired)
Vision sensing technology
Santa Clara, CA
Mozart Therapeutics
Autoimmune disease therapeutics
Seattle, WA
Nanophase Technologies
Ultra-fine ceramic materials
Romeoville, IL | NASDAQ: NANX
Nano-based materials for electronics/sensors
Milpitas, CA
National Resilience
Re-engineering drug manufacturing in the U.S. and abroad
La Jolla, CA
NetBot (Acquired)
Intelligent agents for online shopping
Redwood City, CA
Neumora Therapeutics
Precision medicines for brain diseases and disorders.
Watertown, MA
NeurogesX (Acquired)
Topical hi-dose capsaicin
San Francisco, CA | NASDAQ: NGSX
New Era of Networks (Acquired)
Enterprise application integration & software
Englewood, CO | NASDAQ: NEON
Nexcura (Acquired)
Web portal for health information
New York, New York & WA
NiOptics (Acquired)
Non-imaging optics
Maplewood, MN
Nitronex (Acquired)
Gallium nitride-based power transistors
Santa Clara, CA & NC
Nohla Therapeutics
Universal transplant therapeutics
Seattle, WA
Nutcracker Therapeutics
RNA immunotherapies manufacturing platform
Emeryville, CA
Surgical therapeutics
Seattle, WA | NASDAQ: OMER
Omniome (Acquired)
SBB DNA sequencing platform
San Diego, CA
Instruments for nucleic acid purification/isolation
Singapore, SG
Desktop super-resolution microscopy
Oxford, UK
siRNA-base therapeutics
Seattle, WA | NASDAQ: PZRX
PixelEXX Systems
Chicago, IL
Prime Medicine
Advanced CRISPR gene editing technology
Cambridge, MA
PsiOxus Therapeutics
Systemic immune oncology therapies
Abingdon, UK
Inhaled respiratory therapeutics
Lexington, MA | NASDAQ: PULM
Digital diagnostics for molecular detection
Lexington, MA | NASDAQ:  QTRX
Quantum Circuits
Developing the first practical quantum computers
New Haven, CT
R2 Technology (Acquired)
Computer-aided diagnostics systems
Marlborough, MA
Receptos (Acquired)
Targeted drug discovery platform
Summit, NJ & CA | NASDAQ: RCPT
Recuro Health
Digital health platform
Dallas, TX
Remix Therapeutics
Therapeutics to reprogram RNA processing
Cambridge, MA
Rodeo Therapeutics
Seattle, WA
ROME Therapeutics
Harnessing the power of the repeatome to develop a new class of therapies for cancer and autoimmune diseases
New York, NY
Rubius Therapeutics
Red cell therapeutics
Cambridge, MA | NASDAQ: RUBY
Sage Therapeutics
CNS therapeutics
Cambridge, MA | NASDAQ: SAGE
Sana Biotechnology
Creating and delivering engineered cells as medicine
Seattle, WA | NASDAQ: SANA
Scholar Rock
Niche activator therapeutics
Cambridge, MA | NASDAQ: SRRK
Semma Therapeutics (Acquired)
Diabetes therapeutics
Cambridge, MA
Semprius, Inc.
Solar cell technology
Durham, NC
Sesh Therapy
Making mental health accessible and affordable
San Francisco, CA
Sienna Biopharmaceuticals
Aesthetic medicine
Westlake Village, CA | NASDAQ:  SNNA
Siluria Technologies (Acquired)
Chemical manufacturing for natural gas
San Francisco, CA
Singular Genomics Systems
Genomic analysis instrumentation
San Diego, CA | NASDAQ: OMIC
Therapeutics for inflammatory and nero degenerative diseases
Beijing, China
Skyline Therapeutics
Gene and cell therapies for China and the world
Cambridge, MA / Shanghai, China
Skyline Vet Pharma
Animal health therapeutics
Research Triangle Park, NC
Slingshot Biosciences
On-demand synthetic cell platform
Emeryville, CA
Sonoma Bio
T cell therapies for autoimmune and degenerative diseases
San Francisco, CA / Seattle, WA
Syros Pharmaceuticals
Gene-gased cancer therapeutics
Cambridge, MA | NASDAQ: SYRS
Teach.com (Acquired)
Elk Grove Village, IL
Theraclone Sciences
Cancer therapeutics
Seattle, WA
Tome Biosciences
Molecular tools to precisely correct large defects in the genome
Cambridge, MA
Transcenta Holding
Fully integrated antibody-based biotherapeutics company
Suzhou, China & Boston, MA | HKEX: 6628
Treeline Biosciences
Difficult-to-drug molecular targets in oncology
Stamford, CT
Trotana Therapeutics
Medicines targeting RNS binding proteins
San Diego, CA
Trubion Pharmaceuticals (Acquired)
Small modular immuno therapeutics
Washington, DC & WA | NASDAQ: TRBN
Twist Bioscience
Synthetic DNA manufacturing
San Francisco, CA | NASDAQ: TWST
DNA imaging
Cambridge, MA
Unity Biotechnology
Therapeutics for age-related diseases & conditions
San Francisco, CA | NASDAQ: UBX
Univa (Acquired)
Supercomputing grid software
Hoffman Estates, IL
VBI Vaccines
Vaccine therapeutics
Cambridge, MA & Quebec, Canada | NASDAQ: VBIV
VentiRx Pharmaceuticals (Acquired)
Immunoregulatory therapeutics
Summit, NJ & CA
Verve Therapeutics
Gene editing therapies to permanently reduce cardiovascular disease
Cambridge, MA | NASDAQ: VERV
Agricultural biotechnology platform
Durham, NC
Vir Biotechnology
Perpetual vaccine platform
San Francisco, CA | NASDAQ: VIR
Vividion Therapeutics (Acquired)
Protein-based therapeutics
San Francisco, CA
Gene profiling instrumentation and data analysis
Cambridge, MA
Autoimmune & inflammatory disease therapeutics
Seattle, WA
Volastra Therapeutics
Cancer genomics and precision medicines
New York, NY
3D printing for electromechanical assemblies
Somerville, MA
Walden Biosciences
Precision renal therapeutics
Boston, MA
WuXiNextCODE Genomics (Acquired)
Population-based genomics database & diagnostics
Cambridge, MA
XenoPort (Acquired)
Drug delivery vectors
Atlanta, GA | NASDAQ: XNPT
Xtera Communications (Acquired)
Optical amplifiers for long-haul communications